| 钠尿肽C型受体信号通路与心血管疾病 |
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| 引用本文： | 徐娜娜,黄山英,柳子墨,贺红,胡琴.钠尿肽C型受体信号通路与心血管疾病[J].中国病理生理杂志,2011,27(12):2417-2422. |
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| 作者姓名： | 徐娜娜 黄山英 柳子墨 贺红 胡琴 |
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| 作者单位： | 国家教育部和卫生部心血管重塑和功能研究重点实验室,山东大学齐鲁医院心内科,山东 济南 250012 |
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| 基金项目： | 国家自然科学基金资助项目(No.81100204) |
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| 摘 要： | 钠尿肽家族(natriuretic peptides,NPs)主要包括心房钠尿肽(atrial natriuretic peptide, ANP)、脑钠尿肽(brain natriuretic peptide, BNP)和C型钠尿肽(C-typenatriuretic peptide, CNP)3类,新发现的还有曼巴蛇钠尿肽、尿扩张素及在澳大利亚大班蛇毒液中的一类钠尿肽样肽类1].
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| 关 键 词： | 受体 钠尿肽 钠尿肽类 磷脂酶C 心肌细胞 成纤维细胞 血管平滑肌细胞 |
| 收稿时间： | 2011-04-27 |
Signaling pathway of natriuretic peptide C receptor in cardiovascular diseases |
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| XU Na-na,HUANG Shan-ying,LIU Zi-mo,HE Hong,HU Qin.Signaling pathway of natriuretic peptide C receptor in cardiovascular diseases[J].Chinese Journal of Pathophysiology,2011,27(12):2417-2422. |
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| Authors: | XU Na-na HUANG Shan-ying LIU Zi-mo HE Hong HU Qin |
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| Institution: | Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Shandong University Qilu Hospital, Jinan 250012, China. |
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| Abstract: | Natriuretic peptide C receptor(NPR-C) has been described,at the time of its discovery,as a clearance receptor of natriuretic peptides(NPs) devoid of any physiological functions and does not contain a guanylyl cyclase domain.However,accumulated evidence indicates recently that NPR-C is coupled to an inhibitory heterotrimeric G protein,thus inhibiting the activity of adenylyl cyclase,decreasing intracellular cAMP levels and activating phospholipase C.NPs have an important role in the heart and vasculature tha... |
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| Keywords: | Receptors natriuretic peptide Natriuretic peptides Phospholipase C Cardiomyocytes Fibroblasts Vascular smooth muscle cells |
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