Gusanlungionosides A-D, potential tyrosinase inhibitors from Arcangelisia gusanlung |
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| Authors: | Yu Ling-Ling Hu Wei-Cheng Ding Gang Li Rong-Tao Wei Jian-He Zou Zhong-Mei Wang Myeong-Hyeon |
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| Affiliation: | Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China. |
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| Abstract: | Four new megastigmane glycosides, named gusanlungionosides A-D (1-4), together with 10 known compounds (5-14), were isolated from the stems of Arcangelisia gusanlung. The structures and absolute configurations of 1-4 were elucidated by comprehensive analysis of their NMR and CD data. Compounds 1-4 exhibited strong inhibitory effects not only on the mushroom tyrosinase activity in vitro but also on melanogenesis in cells. |
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