Follicular variant of peripheral T-cell lymphoma mimicking follicular lymphoma: a case report with a review of the Literature |
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Authors: | Goto Naoe Tsurumi Hisashi Sawada Michio Kanemura Nobuhiro Hara Takeshi Kasahara Senji Kito Yusuke Takada Katsuyoshi Sato Yasuharu Yoshino Tadashi Moriwaki Hisataka Takami Tsuyoshi |
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Affiliation: | First Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan. naoegoto@gifu-u.ac.jp |
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Abstract: | Peripheral T-cell lymphoma (PTCL) with a follicular growth pattern is very rare. Herein, a case of follicular variant of PTCL in a 50-year-old man who complained of tonsillar and generalized lymph node swelling is reported. The resected tonsil revealed a vague nodular growth pattern of atypical cells, medium to large in size, with abundant pale cytoplasm. The lymphoma cells were CD3(+) CD4(+) CD5(+) CD8(-) CD10(+) CD56(-) CD57(-) BCL6(+) PD-1(+) CXCL13(+) and were associated with a meshwork of CD21(+) follicular dendritic cells. Molecular studies revealed clonal rearrangement of the T-cell receptor gamma chain gene but not of the immunoglobulin gene. Cytogenetic analysis disclosed a complex abnormality in 18 of 20 cells with the exclusion of t(5; 9). These findings suggest that the present case is a follicular variant of PTCL derived from follicular T-helper cells. |
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Keywords: | follicular variant PTCL follicular T‐helper cells phenotype |
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