| 豆豉及其多糖对α-葡萄糖苷酶抑制作用的研究及豆豉中降糖有效成分的初步分析 |
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| 引用本文： | 郭瑞华,翟丽,刘正猛,王和平,赵运森,孙艳美,邹洪波. 豆豉及其多糖对α-葡萄糖苷酶抑制作用的研究及豆豉中降糖有效成分的初步分析[J]. 中药材, 2005, 28(1): 38-40 |
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| 作者姓名： | 郭瑞华 翟丽 刘正猛 王和平 赵运森 孙艳美 邹洪波 |
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| 作者单位： | 华北煤炭医学院,河北唐山,063000 |
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| 摘 要： | 目的:探讨豆豉(永川豆豉)及其多糖对α-葡萄糖苷酶活力的影响及豆豉中降糖有效成分的初步分析.方法:豆豉水提液通过浸提、离心制得;豆豉经热水提取、低温减压浓缩、三氯醋酸洗去蛋白、流水透析、Sephadex G-50柱层析分离纯化、制得豆豉多糖.酶活性用PNPG法测定.结果:豆豉及其多糖对α-葡萄糖苷酶有抑制作用.结论:豆豉及其多糖可能具有拜糖平样的降糖作用,豆豉中可能含有苯丙氨酸衍生物.
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| 关 键 词： | 豆豉 α-葡萄糖苷酶 降糖作用 |
| 修稿时间： | 2004-08-24 |
Study on Inhibition on α-glucosidase and Analysis of the Hypoglycemic Composition of Lobster Sauce |
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| Guo Ruihua,Zhai Li,Liu Zhengmeng,Wang Heping,Zhao Yunsen,Sun Yanmei,Zou Hongbo. Study on Inhibition on α-glucosidase and Analysis of the Hypoglycemic Composition of Lobster Sauce[J]. Journal of Chinese medicinal materials, 2005, 28(1): 38-40 |
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| Authors: | Guo Ruihua Zhai Li Liu Zhengmeng Wang Heping Zhao Yunsen Sun Yanmei Zou Hongbo |
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| Affiliation: | North China Coal Medical College, Tangshan 063000. |
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| Abstract: | OBJECTIVE: To study the effects of lobster sauce and polysaccharide extracts on alpha-1,4-glucosidase activity by establishing on enzyme-inhibitor model. METHODS: Glucosidase activity was assayed at PH optima by PNPG substrate. Lobster sauce extracts were prepared by soaking, centrifagation. Polysaccharide were prepared by soaking, centrifagation, separation. RESULTS: Lobster sauce and polysaccharide can inhibit alpha-1,4-glucosidase. CONCLUSION: This finding suggested that their hypoglycemic mechanism was similar to Acarbose. Lobster sauce may contain phenyalanine. |
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