| 6年随访1例伴染色体1,11核型异常演变的骨髓增生异常综合征 |
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| 引用本文： | 吕鑫,仇红霞,仇海荣,张苏江,许戟,徐卫,吴汉新,李建勇,邵景章. 6年随访1例伴染色体1,11核型异常演变的骨髓增生异常综合征[J]. 中国实验血液学杂志, 2010, 18(2): 469-472 |
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| 作者姓名： | 吕鑫 仇红霞 仇海荣 张苏江 许戟 徐卫 吴汉新 李建勇 邵景章 |
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| 作者单位： | 1. 南京医科大学第一附属医院、江苏省人民医院血液科,江苏南京,210029
2. 苏州大学第一附属医院血液科 |
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| 摘 要： | 本研究探讨骨髓增生异常综合症-原始细胞增多型(MDS-RAEB)患者的染色体核型演变与疾病进展的关系。通过对1例MDS-RAEB-II患者长达6年的随访,动态检测染色体核型、骨髓以及血常规,并采用荧光原位杂交技术(FISH)对患者的异常核型进行验证。结果表明,随访72个月中发现急性髓系白血病型化疗对患者无效,而全反式维甲酸、6-巯基嘌呤的诱导及支持治疗对患者有效。在初诊时为正常男性核型,病程第48月出现核型演变46,XY,2q+[1]/46,XY[19],第56月演变为46,XY,dup(1q)[3]/46,XY[7],第68月出现以dup(1)和der(11)为主的复杂染色体异常,并有血小板进行性下降。结论:染色体核型的演变与骨髓增生异常综合症疾病的进展可能有相关性。
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| 关 键 词： | 骨髓增生异常综合症 染色体1 染色体11 核型异常 |
A Case of Myelodysplastic Syndrome with Aberrant Evolution of Chromosome I and 11 in 6 years of Follow-up |
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| LU Xin,QIU Hong-Xia,QIU Hai-Rong,ZHANG Su -Jiang,XU Ji,XU Wei,WU Han-Xin,LI Jian- Yong,SHAO Jing-Zhang. A Case of Myelodysplastic Syndrome with Aberrant Evolution of Chromosome I and 11 in 6 years of Follow-up[J]. Journal of experimental hematology, 2010, 18(2): 469-472 |
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| Authors: | LU Xin QIU Hong-Xia QIU Hai-Rong ZHANG Su -Jiang XU Ji XU Wei WU Han-Xin LI Jian- Yong SHAO Jing-Zhang |
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| Affiliation: | (Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing , 210029, Jiangsu Province, China) |
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| Abstract: | This study was aimed to investigate the relationship between cytogenetic evolution and disease progression in patient with MDS-RAEB.By a long term(6 years) follow-up of a patient with MDS-RAEB,peripheral blood cell count,bone marrow cell morphology and conventional cytogenetics were monitored regularly.In addition,fluorescence in situ hybridization(FISH) was applied to confirm the aberrant karyotype.The results indicated that this patient was failed with conventional chemotherapy of AML,but had response to ... |
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| Keywords: | myelodysplastic sydrome chromosome 1 chromosome 11 karyotype aberration |
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