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Brain receptor binding of analogues of gamma-aminobutyric acid (GABA) |
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| Authors: | P A Borea A Bonora P G Baraldi D Simoni |
| Abstract: | This paper reports the synthesis of some 4-(beta-hydroxyalkyl)-gamma-aminobutyric acid analogues (I a-h). The compounds were biologically tested as inhibitors of 3H-GABA binding to rat cortex synaptosomal membranes. The most potent compounds were (I c,d) which exhibited a linear alkyl chain at C4. |
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