特比萘芬与复方酮康唑治疗皮肤真菌病的比较

目的 :特比萘芬与复方酮康唑治疗皮肤真菌病的疗效比较。方法 :患浅部真菌病病人 6 0例 ,男性 4 1例 ,女性 19例 ,年龄 (2 9±s 9)a ,随机分为特比萘芬组 30例 ,应用特比萘芬软膏外涂患处 ,bid× 2wk ;复方酮康唑组 30例 ,外用复方酮康唑霜剂 ,bid× 2wk ;在停药时及停药 2wk后观察疗效。结果 :治疗结束时 ,特比萘芬组总有效率为 73% (2 2 /30 ) ,复方酮康唑组为 57% (17/30 ) ,P >0 .0 5;停药 2wk后 ,特比萘芬组总有效率为 97% (2 9/30 ) ,复方酮康唑组为 4 7% (14/30 ) ,P <0 .0 5。治疗结束时 ,特比萘芬组真菌清除率为 83% ,复方酮康唑组为 53% ,P <0 .0 5,停药 2wk后 ,特比萘芬组真菌清除率为 97% (复方酮康唑组为 37% ,P <0 .0 1)。 2组均未见不良反应。结论 :特比萘芬治疗浅部真菌病优于复方酮康唑。

Terbinafine vs compound ketoconazole in treating dermatomycosis

AIM: To compare the therapeutic effects of terbinafine and compound ketoconazole in treatment of dermatomycosis. METHODS: Sixty patients (M 41, F19, age 26± s 9 a) with dermatomycosis were randomly divided into 2 groups. Thirty patients were treated with terbinafine, bid for 2 wk. Thirty patients were treated with compound ketoconazole bid for 2 wk. The drug effects were evaluated after the treatment. RESULTS: The total effective rates at the end of treatment were 73 % (22/30) for terbinafine group and 57 %(17/30) for compound ketoconazole group ( P >0.05); and 97 % (29/30) for terbinafine group and 47 % (14/30) for compound ketoconazole group ( P <0.05) at 4 wk. Mycological clearance rates at 2 weeks were 83 % for terbinafine group and 53 % for compound ketoconazole group ( P <0.05); and 97 % for terbinafine group and 37 % for compound ketoconazole group ( P <0.01) at 4 weeks. There were no adverse reactions in both treatment groups. CONCLUSION: Terbinafine is better than compound ketoconazole in the treatment of dermatomycosis.