RC-RNase-induced cell death in estrogen receptor positive breast tumors through down-regulation of Bcl-2 and estrogen receptor |
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Authors: | Tseng Hsu-Hung Yu Yung-Luen Chen Yi-Lin Sophia Chen Jia-Hui Chou Chu-Lin Kuo Tsun-Yung Wang Jaang-Jiun Lee Ming-Chieh Huang Ting-Han Chen Mark Hung-Chih Yiang Giou-Teng |
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Affiliation: | Department of Emergency Medicine, Buddhist Tzu-Chi University and General Hospital, Hualien and Taipei Branch, Taiwan. |
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Abstract: | RC-RNase exerts anti-cancer effects on many tumors. However, the mechanisms by which RC-RNase induces cytotoxicity in different tumor cells are unclear. Currently, estrogen receptor (ER)-positive and negative breast tumors are treated with RC-RNase. Our data demonstrate that RC-RNase induces cell death on ER-positive but not on ER-negative breast tumors. This study also shows that down-regulation of ER and Bcl-2 is found on RC-RNase-treated ER-positive breast tumors. Additionally, Bcl-2 overxpression can prevent ER-positive breast tumors from cell death treated with RC-RNase. In summary, this study demonstrates that RC-RNase-induced cell death of ER-positive breast tumors is through regulation of ER and Bcl-2. |
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