Brazilian normal static bone histomorphometry: effects of age,sex, and race |
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Authors: | Luciene M Dos Reis João R Batalha Daniel R Muñoz Aurélio Borelli Pedro HS Correa Aluizio B Carvalho Vanda Jorgetti |
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Institution: | 1.Department of Nephrology, School of Medicine,University of Sao Paulo,S?o Paulo,Brasil;2.Department of Endocrinology, School of Medicine,University of Sao Paulo,Sao Paulo,Brazil;3.Department of Legal Medicine, School of Medicine,University of Sao Paulo,Sao Paulo,Brazil;4.Department of Radiology, School of Medicine,University of Sao Paulo,Sao Paulo,Brazil;5.Institute of Biomedical Sciences, Department of Physiology and Biophysics,University of Sao Paulo,Sao Paulo,Brazil;6.Division of Nephrology, Department of Medicine,Federal University of Sao Paulo,Sao Paulo,Brazil;7.Discipline of Clinical Medicine, Department of Medicine,Federal University of Sao Paulo,Sao Paulo,Brazil |
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Abstract: | Bone histomorphometry values for normal individuals within different populations have been well established. We studied iliac
crest bone samples from 125 healthy Brazilian subjects. The effect of sex, race, and age variables on histomorphometric parameters
was evaluated. Bone volume showed a trend to decrease with age in both sexes, being significantly higher in black females
and Caucasian males. Interactions among sex, race, and age had no effect on trabecular thickness (Tb.Th) and trabecular separation
(Tb.Sp). However, age had a significant effect on Tb.Th and Tb.Sp, and sex had an impact on Tb.Sp. Trabecular number (Tb.N)
was higher in black females than in males and was higher in Asian males than in females. Among females, Tb.N was lower in
Asians than in other races and was higher in blacks than in Caucasians and or in those of mulattos. In addition, Tb.N was
higher in males under 10 than in males over 50 years old, was higher in females under 10 than in females in any other age
bracket, and was lower in females in the 41–50 age bracket than in younger females. Osteoid volume and osteoid surface were
significantly higher in males than in females, and a significant age-related difference in osteoid thickness was observed.
No significant sex-related or race-related differences were found in terms of resorption, although eroded surface decreased
with age. In conclusion, sex, race, and age, as well as interactions among these three variables, were found to affect some
static histomorphometric indexes in healthy Brazilian subjects. |
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Keywords: | bone histomorphometry age-related bone loss race and sex differences normal iliac bone |
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