肾移植患者他克莫司血药浓度监测的临床分析

目的：研究肾移植患者术后不同时间他克莫司血药浓度的监测情况，为临床使用他克莫司提供参考。方法：以110例肾移植患者为研究对象，统计分析术后时间、用药剂量、性别、年龄等因素与他克莫司血药浓度的关系。结果：肾移植手术1个月后，他克莫司用药剂量、血药浓度随术后时间的延长而逐渐下降，且血药浓度个体差异较大；同一时间段内，性别对血药浓度影响不大（P〉0．05）；术后同一时间段内，C组（年龄〉60岁）用药剂量、血药浓度均低于A组（年龄13-45岁）和B组（年龄45-60岁）（P〈0．05），A、B组用药剂量、血药浓度未见明显差异（P〉0．05）。结论：他克莫司血药浓度监测可防止免疫过度、不足和药物毒性，有利于提高移植肾的长期存活率。

Clinical Analysis of Blood Concentration Monitoring of Tacrolimus in Renal Transplantation Recipients

OBJECTIVE： To study the blood concentration monitoring of tacrolimus （Tac） in renal transplantation recipients, and to provide reference for use of Tac in the clinic. METHODS： 110 renal transplantation recipients were selected, and relation- ship of post-operative time, dosage, gender, age with blood concentration of Tac was analyzed statistically. RESULTS： The dose and blood concentration of Tac decreased gradually with time 1 month after transplantation, with great individual difference. The gender had small effect on blood concentration of Tac at the same period （P〉0.05）. The blood concentration and dose of Tac in group C （〉60 years old） were lower than in group A （13-45 years old） and group B （45-60 years old） after operation （P〈 0.05） ; the blood concentration and dose of Tac had no significant difference between group A and group B （P〉0.05）. CONCLU- SION： It is necessary to monitor the blood concentration of Tac to avoid excessive and insufficient immunity, toxic responses and improve the kidney survival rate.