老年2型糖尿病合并骨质疏松症患者发病韵相关因素分析

目的探讨老年2型糖尿病合并骨质疏松症患者发病的相关危险因素。方法对本院106例老年2型糖尿病合并骨质疏松症患者的年龄、体重指数（BMI）、糖尿病病程与其骨密度（BMD）进行相关因素分析。结果老年2型糖尿病合并骨质疏松症患者中，80岁组的腰椎[（0．756±0．099）g／cm^2]、股骨颈[（0．658±0．111）g／cm^2]及Wards三角[（0．525±0．064）g／cm^2]BMD值较60岁组[（0．883±0．112）g／cm^2、（0．781±0．130）g／cm^2、（0．6274±0．118）g／cm^2]明显下降（P〈0．05）。低体重组（BMI≤20kg／m^2）的腰椎[（0．738±O．114）g／cm^2）]、股骨颈[（0．664±O．112）g／cm^2）]BMD值较正常体重组[（0．816±0．138）g／cm^2、（0．727±0．134）g／cm^2]明显下降（P〈0．05）。糖尿病病程〉10年组的腰椎[（0．743±O．122）g／cm^2]、股骨颈[（0．719±0．147）g／cm^2]BMD值较病程〈5年组[（0．886±0．132）g／cm^2、（0．792±0．122）g／cm^2]明显下降（P〈0．05）。骨密度与年龄、糖尿病病程呈负相关（P〈0．05），与体重指数呈正相关（P〈0．05）。结论老年2型糖尿病合并骨质疏松症患者发病与高龄、低体重指数、糖尿病病程长的危险因素密切相关。

Correlation factor analysis in older type 2 diabetes patients with osteoporosis

Objective To investigate the correlation factors in older type 2 diabetes patients with osteoporosis. Methods The related risk factors including their age, body mass index（ BMI）, history of dis- ease and bone mineral density（ BMD）were analyzed in 106 older type 2 diabetes patients with osteoporosis, who were hospitalized in the first affiliated hospital of Guangzhou Medical College during January 2000 to December 2010. Results BMD of lumbar[ （0. 756 ± 0. 099）g/cm^2 ], neck of femur [ （0. 658 ± 0. 111 ） g/cm^2] and wards triangle[ （0. 525 ± 0. 064）g/cm^2] in the eighty group were distinctly reduced than the sixty group [ （0. 883 ± 0. 112） g/cm^2, （0. 781 ± 0. 130） g/cm2, （ 0. 627 ± 0. 118 ） g/cm^2] （ P 〈 0. 05 ）. BMD of lumbar[ （0. 738 ± 0. 114） g/cm^2 ） ] and neck of femur [ （ 0. 664 ± 0. 112 ） g/cm2 ） ] in low weight patients （BMI≤20 kg/m2） were distinctly reduced than normal BMI group [ （0. 816±0. 138 ）g/cm^2, （0. 727± 0. 134） g/cm^2 ] （ P 〈 0. 05 ）. BMD of lumbar [ （ 0. 743 ± 0. 122 ） g/cm^2 ] and neck of femur [（ 0. 719±0. 147） g/cm2 ] in patients with course of diabetes more than 10 years were distinctly reduced than the pa- tients with less course[ （0. 886±0. 132 ） g/cm^2, （ 0. 792 ± 0. 122 ） g/cm^2 ] （ P 〈 0. 05 ）. BMD was nega- tively correlated with age and history of diabetes（ P 〈 0. 05）. BMD was positively correlated with BMI（ P 〈 0. 05 ）. Conclusions Older, low BMI and long history of diabetes are the risk factors of older type 2 di- abetes patients with osteoporosis.