Tubular biomarkers to assess progression of diabetic nephropathy |
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Authors: | Tramonti Gianfranco Kanwar Yashpal S |
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Institution: | Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA. |
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Abstract: | Despite aggressive management, many patients with diabetic nephropathy still develop end-stage renal disease. Accompanying tubulointerstitial damage is important in the progression of diabetic nephropathy. Markers of tubular damage, such as NGAL, KIM-1, and LFABP, have been proposed for monitoring the effectiveness of therapy. However, Nielsen et al. report a lack of an independent correlation between these biomarkers and glomerular filtration rate. Therefore, these markers seem to offer no improvement in the management of diabetic nephropathy. |
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