Regulation of cell survival during renal development |
| |
Authors: | Marc R Hammerman |
| |
Institution: | (1) George M. O’Brien Kidney and Urological Disease Center, Renal Division, Departments of Medicine, Pathology and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA, US |
| |
Abstract: | Apoptosis occurs in an orchestrated fashion during kidney development. In contrast, it is a relatively rare event in normal
developed (adult) kidney. However, a predictable pattern of apoptosis is observed in adult kidney in two settings, during
which parts of the developmental pattern are recapitulated. These are regeneration following acute ischemic injury and the
process of cystogenesis in polycystic kidney disease. Apoptosis in kidney is regulated by agents both intrinsic and extrinsic
to the renal cell. The protooncogene b-cell lymphoma/leukemia gene product-2 (bcl-2) is an important intrinsic factor. The
growth factor epidermal growth factor is an important extrinsic regulator. A thorough understanding of the control of renal
apoptosis during development and recovery from ischemic injury and in cystogenesis may lead to new therapies to prevent or
ameliorate abnormalities of kidney formation, to enhance regeneration following acute ischemic injury, and to slow the progression
of renal failure in polycystic kidney disease.
Received October 14, 1997; received in revised form December 10, 1997; accepted January 28, 1998 |
| |
Keywords: | : Acute renal failure Apoptosis b-Cell lymphoma/leukemia gene product-2 Growth factor Polycystic kidney disease |
本文献已被 SpringerLink 等数据库收录! |
|