胰岛素抵抗综合征与凝血作用、血小板功能和纤维蛋白溶解作用异常

医学术语“代谢综合征”至少存在两个有疑问的背景:①它是否只是简单的反映发生在冠状动脉疾病事件上的几个危险现象。②冠心病危险的增高不被认为是与胰岛素抵抗有确切关联的原因。与胰岛素抵抗相伴的肥胖、高血压、多囊卵巢综合征和2型糖尿病早期都有促血栓形成的情况,这种促血栓形成的情况是高胰岛素血症以及与之相关的代谢异常在血小板、凝血、纤溶方面直接作用的反应,增加胰岛素敏感性的治疗可以减少胰岛素抵抗和高胰岛素血症,并能降低促血栓形成的状态。

Abnormalities of Coagulation,Platelet Function,and Fibrinolysis and Insulin Resistance Syndromes

Medical terminology "metabolic syndrome " has two doubltful background at least: ①whether it just reflect several risk phenomenna in coronary artery disease cases or not ②increased danger of coronary heart diaseases can not be considered to has identified relationship with insulin resistance.There are thrombosis-promoting condition in insulin resisitance accompanyed by obesity,hypertension,polycystic ovarian syndrome and type 2 diabetes mellitus,which is the direct reponse of hyperinsulinism and releted metabolitic abnormality in platelet,blood coagulation and fibrinolysis.Therapy increasing insulin sensitivity can reduce insulin resistance and hyperinsulinism,and decrease thrombosis-promoting condition.