Coupling daunorubicin to monoclonal antialphafoetoprotein with a new activated derivative. |
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| Authors: | D Thibeault M Pagé |
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| Affiliation: | Department of Biochemistry, Faculty of Medicine, Université Laval, Sainte-Foy, Québec, Canada. |
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| Abstract: | We report the synthesis of daunorubicin antialphafoetoprotein conjugates, using a new coupling method. At equimolar concentrations on AFP producing cells in vitro, these conjugates were found three times as cytotoxic as the free drug. |
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