胰岛素抵抗与脑血管病危险因素聚集性关系的研究

目的：探讨胰岛素抵抗与脑血管病危险因素聚集性的关系。方法；采用常规方法测定９１例动脉硬化性脑梗死和６８例高血压性脑出血患者和４０例健康人的空腹血糖、胰岛素、血脂、ｔ－ＰＡ，ＰＡＩ－Ｉ和血压水平。结果：研究对象按脑血管病危险因素数目分为４组，随着危险因素增加，各组胰岛素敏感性指数（ＩＳＩ）逐渐降低。脑卒中患者抵抗与脑血现危险因素聚集性密切相关（Ｐ〈０．０１），与ＨＤＬ正相关（Ｐ〈０．０１）。结论：胰

Relationship between insulin resistance and clustering of risk factors of cerebrovascular disease]

OBJECTIVE: To study the relationship between insulin resistance and clustering of risk factors of cerebrovascular disease. METHODS: The serum concentrations of fasting glucose, insulin, lipids, the activities of tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1(PAI-1), and the level of blood pressure were measured in 159 patients with stroke and 40 healthy control subjects. RESULTS: All subjects were divided into 4 groups in the light of number of risk factors of cerebrovascular disease. As the number of risk factors increased, the insulin sensitivity index (ISI) in four groups gradually decreased. The ISI in the patients with cerebrovascular disease was negatively associated with increased levels of SBP, DBP, TG, APOB, and PAI-1 activity (P < 0.01) and positively with decreased level of HDL (P < 0.01). CONCLUSION: Insulin resistance is associated with clustering of risk factors of cerebrovascular disease, the more resistant, the more clustered.