北京市2007年健康人群脊髓灰质炎抗体水平分析

目的了解北京市2007年健康人群脊髓灰质炎（脊灰）抗体水平。方法采用分层多级抽样的方法，调查北京市7个区（县）的〈1、1～4、5～9、10～14、15～19、20-24、25-29、30-34、35-39、≥40岁健康人群共1552人，用微量细胞中和试验测定血清脊灰中和抗体。结果脊灰中和抗体Ⅰ、Ⅱ、Ⅲ型阳性率分别为97．04％、97．29％、91．04％：抗体几何平均滴度（Geometric Mean Titers，GMT）分别为1：70．05、1：54．60、1：31．83。抗体GMT随年龄增长和免疫后时间延长而逐渐下降。不同性别、户籍、地区间抗体水平差异无显著的统计学意义。多因素分析发现，年龄组和免疫后时间对抗体GMT的影响有统计学意义。结论北京市健康人群对脊灰形成了免疫屏障。

Analysis of Polio Antibody Levels in Healthy Population in Beijing in 2007

Objective To investigate the poliomyelitis antibody level in healthy people in Beijing. Methods 10 age groups （0, 1 to 4, 5 to 9, 10 to 14, 15 to 19, 20 to 24, 25 to 29, 30 to 34, 35 to 39, and ≥ 40） were sampled by the Multi-stage stratified sampling method in 7 districts in Beijing, and 1552 sera from healthy population were collected. The poliomyelitis antibody was determined with microcell neutralization method. Results The neutralized antibody-positive rate for polio Ⅰ,Ⅱ,Ⅲ were 97.04%, 97.29% and 91.04% respectively, the geometric mean titers （GMT） were 1：70.05, 1：54.60, and1：31.83 respectively. A trend of decreasing was observed in the GMTs with increasing age and years after immunization. There were no significant differences in antibody levels between different gender, residents or regions. The results of multiple-factors analysis showed that the GMTs were significantly associated with age and the years after immunization. Conclusion A stable immunization barrier has been established in healthy population in Beijing.