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| 桑枝、桑白皮体外降糖作用研究 | |
| 引用本文： | 汪宁,朱荃,周义维,童黄锦. 桑枝、桑白皮体外降糖作用研究[J]. 中药药理与临床, 2005, 21(6): 35-36 |
| 作者姓名： | 汪宁 朱荃 周义维 童黄锦 |
| 作者单位： | 1. 南京中医药大学国家规范化中药药理实验室,南京,210029;安徽中医学院药学院,合肥,230038 2. 南京中医药大学国家规范化中药药理实验室,南京,210029 3. 安徽中医学院药学院,合肥,230038 |
| 基金项目： | 安徽省高校青年教师科研项目 |
| 摘 要： | 目的:研究桑枝、桑白皮体外降糖作用,初步探讨其降糖作用机理.方法:采用与人肝细胞表型相似的HepG2细胞,检测24h后培养液中葡萄糖的消耗量,用MTT法监测细胞增殖的情况.结果:桑枝、桑白皮在高糖状态下可使HepG2细胞的葡萄糖消耗量增加,对胰岛素刺激的HepG2细胞的葡萄糖消耗量增加有协同作用.结论:促进外周组织的葡萄糖代谢、提高肝细胞对胰岛素的敏感性可能是桑枝、桑白皮防治2型糖尿病作用的机理之一. |
| 关 键 词： | HepG2细胞 桑枝 桑白皮 葡萄糖消耗 |
Study on hypoglycemic effects of extracts of Ramulus Mori (桑枝) and Cortex Mori (桑白皮) in vitro |
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| Wang Ning,Zhu Quan,Zhou Yiwei,Tong Huangjing. Study on hypoglycemic effects of extracts of Ramulus Mori (桑枝) and Cortex Mori (桑白皮) in vitro[J]. Pharmacology and Clinics of Chinese Materia Medica, 2005, 21(6): 35-36 | |
| Authors: | Wang Ning Zhu Quan Zhou Yiwei Tong Huangjing |
| Affiliation: | 1 National Standard Laboratory of Pharmacology for Chinese Materia Medicine, Nanjing University of TCM, Nanjing 210029 ; 2 Department of Pharmacy, Anhui College of TCM, Hefei 230038 |
| Abstract: | Objectsive:To observe the effects of extracts of Ramulus Mori and Cortex Mori on glucose uptaking in cultured HepG2 cells in vitro andinvestigate the hypoglycemic mechanism of them initially.Methods:HepG2 cells ,the phenotype of which is similar to that of the humanhepatocytes , were used to detect the 24 hours, consumption of glucose in cultured fluid , MTTassay was used to monitor the proliferation ofthe HepG2 cells.Results:Ramulus Mori and Cortex Mori could increase the glucose consumption of HepG2 cells and enhance the glucoseconsumption in coordination with insulin.Conclusions:Promoting the glucose uptake rate of peripheral tissue and enhance the sensitivity ofhepatocytes to insulin may be one of the possible hypoglycemic mechanisms of Ramulus Mori and Cortex Mori. |
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