| 锂盐神经保护作用机制的研究进展 |
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| 引用本文： | 许夕慧,顾振纶,秦正红.锂盐神经保护作用机制的研究进展[J].中国新药杂志,2006,15(2):87-92. |
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| 作者姓名： | 许夕慧 顾振纶 秦正红 |
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| 作者单位： | 苏州大学医学院药理教研室,苏州,215007 |
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| 基金项目： | 中国科学院资助项目;江苏省自然科学基金 |
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| 摘 要： | 锂盐作为治疗躁狂抑郁症的主要药物，在近年来的研究中发现它在体内外均具有很好的神经保护作用，可用于治疗阿尔茨海默病、亨廷顿舞蹈病和脑缺血等脑血管疾病。其神经保护作用机制涉及多个方面，包括糖原合酶激酶，3、NMDA离子通道、bcl-2蛋白家族、脑源性神经营养因子信号传导通路、丝裂原激活的蛋白激酶信号传导通路、c-fos及c-jun，目前尚未完全阐明。综述锂盐的神经保护作用及其机制的研究进展。
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| 关 键 词： | 锂盐 神经保护作用 神经退行性疾病 糖原合酶激酶-3 |
| 文章编号： | 1003-3734（2006）02-0087-06 |
| 收稿时间： | 2005-07-08 |
| 修稿时间： | 2005年7月8日 |
Neuroprotective actions and underlying molecular mechanisms of lithium |
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| XU Xi-hui,GU Zhen-lun,QIN Zheng-hong.Neuroprotective actions and underlying molecular mechanisms of lithium[J].Chinese Journal of New Drugs,2006,15(2):87-92. |
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| Authors: | XU Xi-hui GU Zhen-lun QIN Zheng-hong |
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| Institution: | Department of Pharmacology, Soochow University School of Medicine, Suzhou 215007, China |
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| Abstract: | Lithium is the one of main drugs used for treatment of manic-depression disease. Although intensive researches have been dedicated to lithium's neuroprotection, the molecular mechanisms by which lithium protects neurons against various pathogenic stimuli are not fully understood yet. Currently, several signaling pathways, including glycogen synthase kinase-3, NMDA receptors, B-cell lymphomal /leukemia-2 gene protein, brain-derived neurotrophic factor, mitogen-activated protein kinase, and c-fos and c-jun, are assumed to link with the lithium's neuroprotective actions. This paper reviewed recent progresses in the studies of lithium's neuroprotection. |
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| Keywords: | lithium neuroprotection neurodegenerative disease glycogen synthase kinase-3 |
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