老年晚期结直肠癌患者术后早期中医辨证分型及预后标志物表达情况分析

目的:分析老年晚期结直肠癌患者术后早期中医辨证分型情况及预后标志物表达情况。方法:选择2014年1月至2016年1月就诊的80例老年晚期结直肠癌患者,对其术后早期症状进行中医辨证分型,同时分析不同证型患者术后预后标志物表达情况。结果:老年结直肠癌患者术后早期中医证型中,湿热瘀毒型及肝肾阴虚型分别占30%及31.25%,明显高于其他3种证型,差异有统计学意义(P0.05);湿热瘀毒型及肝肾阴虚型患者术后血清癌胚抗原(CEA)、糖类抗原125(CA_(125))水平及肿瘤特异性生长因子(TSGF)阳性表达率明显高于其他3种证型,差异有统计学意义(P0.05);脾肾两虚型及肝肾阴虚型患者Karnofsky评分≤70分比例明显高于其他3种证型,差异有统计学意义(P0.05)。结论:湿热瘀毒及肝肾功能的变化预示结直肠癌患者预后不良。

The Investigation into Syndrome Differentiation and Classfication of the Elderly Patients after the Surgery of Terminal Rectal Cancer at Early Stage and the Analysis on the Expressions of Prognostic Markers

Objective:To analyze the conditions of syndrome differentiation and classification of the elderly patients after the surgery of terminal colo rectal cancer at the early stage and the expressions of prognostic markers.Methods:Eighty elderly patients suffering terminal colo rectal cancer who visited from January,2014 to January,2016 were chosen,their early symptoms after the operation were differentiated,meanwhile,the expressions of prognostic markers of the patients in different patterns after the operation were analyzed.Results:The patients of dampness-heat and stagnant toxin pattern and liver-kidney Yin-deficiency pattern occupied 30％ and 31.25％ respectively,obviously higher than other three patterns,and the difference showed statistical meaning (P＜0.05);the levels of CEA and CA125,the positive expression rate of TSGF of the patients in dampness-heat and stagnant toxin pattern and liver-kidney Yin-deficiency pattern were notably higher than these of the patients in other three patterns,and the difference demonstrated statistical meaning (P＜0.05);Karnofsky scales of the patients in spleen-kidney dual deficiency pattern and liver-kidney Yin-deficiency pattern less than 70 points,and they were higher than these of the patients in other three patterns,and the difference demonstrated statistical meaning (P＜0.05).Conclusion:The patterns of dampness-heat and stagnant toxin and the changes of liver and renal functions indicate the poor prognosis of the patients suffering rectal cancer.