丹参注射液与黄芪注射液对脑梗死大鼠急性期神经功能和梗死面积的影响

目的:探讨丹参注射液与黄芪注射液对脑梗死大鼠急性期神经功能和梗死面积的影响。方法:将成年SD大鼠80只分为假手术组20只,模型组60只(对照组、研究组A及研究组B各20只)。对照组大鼠术后注射生理盐水,研究组A采用黄芪注射液治疗,1次/d,研究组B采用丹参注射液治疗,1次/d。计算术后1、2、3天及7天4组大鼠死亡率并比较各组大鼠神经功能缺损评分、脑梗死面积比及脑湿重比。结果:研究组A及研究组B大鼠脑梗死急性期的死亡率较对照组有所降低,研究组B效果更明显,与对照组比较差异具有统计学意义(P0.05)。研究组A及研究组B大鼠术后2、3天及7天神经功能缺损评分较对照组有所改善,研究组B改善效果更明显,与对照组比较差异具有统计学意义(P0.05)。研究组A及研究组B大鼠术后7天脑梗死面积较对照组有所下降,差异具有统计学意义(P0.05)。对照组大鼠术后7天脑湿重比高于假手术组及研究组A,差异具有统计学意义(P0.05);研究组B与对照组比较差异无统计学意义(P0.05)。结论:丹参注射液治疗急性期脑梗死可有效改善大鼠神经功能,减少梗死面积及脑组织水肿状态。

The Influences of DanShen Injection and HuangQi Injection on Neurological Function and Infarct Size of Rats with Cerebral Infarction at Acute Stage

Objective:To explore the influences of DanShen injection and HuangQi injection on neurological function and infarct size of rats with cerebral infarction at acute stage. Methods:All 80 adult SD rats were divided into sham operation group (20) and the model group (60)( the control group, the study group A and B, each 20). The control group was given injection of normal saline after surgery, the study group A was given HuangQi injection, once per time, the study group B was given DanShen injection, once per day. Death rate, NIHSS, area of cerebral infarction and brain wet ratio in four groups in one, two, three and seven days after surgery were compared. Results:Death rates of rats with cerebral infarction at acute stage in study group A and B decreased compared with the control group, the study group B had more obvious improvement, there was statistical difference compared with the control group(P<0.05). NIHSS of rats in the study group A and B improved compared with that of the control group in two, three and seven days after surgery, but the study group was improved more obviously, there was statistical difference (P<0.05). Brain wet ratio of rats in the control group in seven days after surgery was higher than that of sham operation and the study group A, there was statistical difference (P<0.05);when the study group B was com-pared with the control group, there were no statistical differences (P>0.05). Conclusion:DanShen injection in treat-ing cerebral infarction in acute stage is accurate, it can improve neurological function of rats, reduce infarct size and edema of cerebral tissue.