消疕合剂治疗血热风燥型进行期寻常型银屑病36例

目的:观察消疕合剂治疗血热风燥型进行期寻常型银屑病的临床疗效。方法:将68例患者随机分为观察组(36例)、对照组(32例),观察组服用消疕合剂,50 m L/次,2次/d;对照组服用消银颗粒,3.5 g/次,3次/d。2组均于连续治疗3个月后观察治疗后前外周血清中肿瘤坏死因子α(TNF-α)和白介素8(IL-8)水平的变化情况及临床疗效。结果:总有效率观察组为88.89%,对照组为62.50%,2组比较差异有统计学意义(P0.05)。血清TNF-α、IL-8水平2组治疗前后组内比较,差异有统计学意义(P0.05);治疗后组间比较,差异也有统计学意义(P0.05)。结论:消疕合剂治疗血热风燥型寻常型银屑病疗效显著,其作用机制可能与调节血清中TNF-α和IL-8的水平有关。

XiaoBi Mixture in Treating 36 Cases of Psoriasis Vulgaris of Blood-heat Wind-dryness Pattern at Active Stage

Objective:To observe clinical effects of XiaoBi mixture in treating psoriasis vulgaris (PV) of blood-heat wind-dryness pattern at active stage.Methods:All 68 patients were randomized into the observation group (36 cases) and the control group (32 cases),the observation group took XiaoBi mixture,50 mL each time,twice each day;the control group orally took XiaoYin granules,3.5 g each time,three times each day.The levels of TNF-α and IL-8 in peripheral blood,and clinical effects were observed before and atter treating when both groups were treated for three months consecutively.Results:Total effective rate of the observation group was 88.89％,higher than 62.50％ of the control group,and the difference showed statistical meaning (P＜0.05).The difference showed statistical meaning in the comparisons of the levels of TNF-α and IL-8 before and after treating within one group (P＜0.05).The difference had statistical meaning in the comparisons between both groups after treating (P＜0.05).Conclusion:XiaoBi mixture is effective in treating PV of blood-heat wind-dryness pattern at active stage,and the mechanism might be related to regulating the levels of TNF-α and IL-8 in the serum.