琥枣宁神胶囊剂与散剂治疗痰热扰心型失眠的疗效比较

目的:比较琥枣宁神胶囊剂与散剂治疗痰热扰心型失眠的临床疗效。方法:将120例患者随机分为观察组、对照组各60例。观察组给予琥枣宁神胶囊,3粒/次,3次/d;对照组给予琥枣宁神散6 g/次,3次/d。2组均连续治疗4周。观察2组在治疗前及治疗4周后匹兹堡睡眠质量指数(PSQI)评分、SPIEGEL量表评分、中医症状积分、睡眠时间及不良反应。结果:总有效率观察组为93.33%,对照组为80.00%,2组比较差异有统计学意义(P0.05)。PSQI及SPIEGEL量表评分2组治疗前后组内比较,差异有统计学意义(P0.05);治疗后组间比较,差异也有统计学意义(P0.05)。中医证候及睡眠时间评分2组治疗前后组内比较,差异有统计学意义(P0.05);治疗后组间比较,差异也有统计学意义(P0.05)。结论:琥枣宁神胶囊剂与散剂均能够改善痰热扰心型失眠患者睡眠质量,胶囊剂疗效优于散剂,且无明显不良反应。

The Comparisons of Clinical Effects of HuZao Tranquilizing Capsules and Powder in the Treatment for Insomnia of Phlegm-heat Attacking the Heart Pattern

Objective:To compare clinical effects of HuZao tranquilizing capsules and powder in treating insomnia of phlegm-heat attacking the heart pattern.Methods:All 120 patients were randomized into the observation group and the control group,60 cases each group.The patients in the observation group were given HuZao tranquilizing capsules,three pills each time,three pills each day,the control group took HuZao tranquilizing powder,6 g each time,three times each day.Both groups were treated for four weeks consecutively.Adverse reaction,sleeping time,TCM symptom scales,SPIEGEL scales and PSQI scales of both groups were observed before treating and in four weeks after treating.Results:Total effective rate of the observation group was 93.33％,higher than 80.00％ of the control group,and the difference had statistical meaning (P＜0.05).The difference showed statistical meaning (P＜0.05) in the comparisons of PSQI and SPIEGEL scales before and after treating within one group;the difference had statistical meaning in the comparisons between both groups after treating (P＜0.05).The difference had statistical meaning in the comparisons of TCM symptom scales and sleeping time before and after treating within one group (P＜0.05);the difference had statistical meaning in the comparisons between both groups after treating (P＜0.05).Conclusion:HuZao tranquilizing capsules and powder could improve sleeping quality of the patients with insomnia of phlegm-heat attacking the heart pattern,clinical effects of the capsules are superior to these of the powder,and it shows no toxic and adverse reactions.