6种肿瘤标志物联合检测在肺癌诊疗中的价值

目的:探讨血清癌胚抗原(CEA)、糖基类抗原125(CA125)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、鳞状细胞癌相关抗原(SCCA)、胃泌素释放肽前体(Pro GRP)肿瘤标志物联合检测在肺癌诊断中的应用价值。方法:以152例肺癌患者、175例肺良性疾病患者和150例健康体检者为观察对象,分别检测血清CEA、CA125、CYFRA21-1、NSE、SCCA和Pro GRP水平。结果:肺癌组6种标志物水平显著高于肺良性疾病组和对照组,差异有统计学意义(P0.05)。腺癌患者血清CEA、CA125水平明显高于鳞癌、非小细胞肺癌和小细胞肺癌,差异有统计学意义(P0.05)。鳞癌CYFRA21-1、SCCA水平较腺癌和小细胞肺癌高,差异有统计学意义(P0.05)。Pro GRP水平小细胞肺癌组显著高于鳞癌和腺癌组,差异有统计学意义(P0.05)。血清肿瘤标志物CEA、CA125、CYFRA21-1、NSE、SCCA和Pro GRP单一检测敏感度均不及联合检测,但联合诊断特异性不及CYFRA21-1和NSE。结论:肿瘤标志物联合检测在肺癌筛查中应用价值较高,但肺癌确诊中联合检测特异性不及某些标志物单一检测。

The Value of Combined Detection of Six Tumor Markers in the Diagnosis and Treatment of Lung Cancer

Objective:To explore the values of combined detection of CEA,CA1n,CYFRA21-1,NSE,SCCAand proGRP in the diagnosis of lung cancer.Methods:All 152 patients with lung cancer,175 patients with benign lung diseases and 150 people undergoing healthy examination were chosen as the objects for observation,to detect the levels of CEA,CA125,CYFRA21-1,NSE,SCCA and ProGRP respectively.Results:The levels of six tumor markers in lung cancer group were higher than these of benign lung diseases group and the control group,and the difference had statistical meaning (P＜0.05).The levels of CEA and CA125 in the patients with glandular cancer were higher than these of the patients with SC,non small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC),and the difference had statistical meaning (P＜0.05).The levels of CYFRA21-1 and SCCA in SC patients were higher than these of the patients with glandular cancer and SCLC,and the difference showed statistical meaning (P＜0.05).The level of ProGRP in SCLC group were higher than these of SC and glandular cancer group,and the difference indicated statistical meaning (P＜0.05).The sensitivity of single tumor marker such as CEA,CA12s,CYFRA21-1,NSE,SCCA and ProGRP was not as good as combined detection,but the specificity of combined detection was not as good as CYFRA21-1 and NSE.Conclusion:The values of combined detection of tumor marker are higher in screening lung cancer,while the specificity of combined detection is not as good as single detection of some marker in the diagnosis of lung cancer.