| 细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶9及P38丝裂原活化蛋白激酶在子宫内膜异位症中的表达及相关性 |
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| 引用本文： | 张婧,唐良萏,周敏,龙行涛. 细胞外基质金属蛋白酶诱导因子、基质金属蛋白酶9及P38丝裂原活化蛋白激酶在子宫内膜异位症中的表达及相关性[J]. 中国实用妇科与产科杂志, 2011, 0(8) |
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| 作者姓名： | 张婧 唐良萏 周敏 龙行涛 |
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| 作者单位： | 重庆医科大学附属第一医院妇产科; |
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| 基金项目： | 国家自然科学基金资助(基金编号:30772034); 重庆市科委计划项目(编号:2007BB5316) |
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| 摘 要： | 目的探讨细胞外基质金属蛋白酶诱导因子(extracellular matrix metalloproteinase inducer,EMMPRIN)、基质金属蛋白酶9(matrix metalloproteinases-9,MMP-9)和P38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)在子宫内膜异位症(endometriosis,EMs)中的表达及相关性。方法收集2008年5-12月重庆医科大学附属第一医院收治的EMs患者44例(异位内膜44例,在位内膜38例),对照组为同期非EMs患者在位内膜34例。应用免疫组化SABC三步法检测各组织中EMMPRIN、MMP-9、P38及磷酸化P385(p-P38)蛋白的表达,并对各蛋白表达水平进行相关性分析。结果 EMMPRIN、MMP-9、P38、p-P38蛋白在EMs异位内膜表达均高于EMs在位内膜组及对照组在位内膜,差异有统计学意义(P<0.05);Spearman相关分析显示,在EMs异位内膜中各蛋白表达呈正相关(P<0.05)。在EMs异位内膜组中各蛋白表达Ⅲ～Ⅳ期高于Ⅰ～Ⅱ期,差异均有统计学意义(P<0....
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| 关 键 词： | 子宫内膜异位症 细胞外基质金属蛋白酶诱导因子 基质金属蛋白酶9 P38丝裂原活化蛋白激酶 免疫组织化学 |
The expression and correlation of EMMPRIN,MMP-9 and P38 MAPK in endometriosis |
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| ZHANG Jing,TANG Liang-dan,ZHOU Min,LONG Xing-tao. The expression and correlation of EMMPRIN,MMP-9 and P38 MAPK in endometriosis[J]. Chinese Journal of Practical Gynecology and Obstetrics, 2011, 0(8) |
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| Authors: | ZHANG Jing TANG Liang-dan ZHOU Min LONG Xing-tao |
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| Affiliation: | ZHANG Jing,TANG Liang-dan,ZHOU Min,LONG Xing-tao. Department of Obstetrics and Gynecology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China |
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| Abstract: | Objective To investigate the expression and association of the extracellular matrix metalloproteinase inducer(EMMPRIN),the matrix metalloproteinases-9(MMP-9),and the P38 mitogen-activated protein kinase(MAPK) in patients diagnosed with endometriosis(EMs).Methods The expression of EMMPRIN,MMP-9,P38,p-P38 was detected by SABC immunohistochemistry in 44 patients with EMs (44 ectopic endometrium,38 eutopic endometrium),and compared with 34 normal endometrium with non-endometriosis.Correlation analysis was done.... |
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| Keywords: | endometriosis EMMPRIN MMP-9 P38 MAPK immunohistochemistry |
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