用于肿瘤代谢显像的几种放射性标记氨基酸

随着代谢显像的广泛应用,放射性标记氨基酸越来越引起临床关注。与18F-FDGPET显像相比,氨基酸显像的优点在于其受炎症的影响较小。对于脑肿瘤,氨基酸代谢显像具有较高的诊断价值。对大多数其它类型的肿瘤而言,尽管凭现有资料尚不能得出最终结论,但其总体可行性已得到充分显示。因此,仍有必要进行经过精心设计的更大样本病例的研究。本文着重描述了11C-蛋氨酸(MET)、11C-酪氨酸(TYR)、123I-甲基酪氨酸(IMT)的基本特性和临床应用。

The clinical application of radiolabeled amino acids in tumor imaging

As the application of metabolic imaging are expanding, radio labeled amino acids may gain increased clinical interest. The fact that amino acid imaging is less influenced by inflammation may be advantageous in comparison with 18F_FDG PET imaging. In brain tumor, the diagnostic value of amino acid imaging is adequate. In most of other tumors, the data do not yet permit definitive conclusions, but the general feasibility of amino acid imaging has sufficiently been shown. More research is required in larger patient series and in well_defined clinical setting. This review mainly describes the basic aspects and clinical applications of 11C_methionine, 11C _tyrosine, and 123I_iodomethytyrosine.