金黄色葡萄球菌对莫匹罗星高水平耐药的研究

目的 了解金黄色葡萄球菌(SAU)对莫匹罗星高水平耐药(MUH)的状况,并探讨其耐药菌株对临床常用抗菌药物的耐药特性.方法 用美国BD公司Phoenix-100型全自动细菌鉴定药敏系统鉴定细菌及做药敏试验,该仪器可以同时检测耐甲氧西林金黄色葡萄球菌(M RSA)和莫匹罗星高水平耐药的金黄色葡萄球菌.结果 共检出金黄色葡萄球菌382株,其中MUH菌株检出25株,检出率为6.5％,其中23株为MRSA,占92.0％；莫匹罗星高水平耐药的金黄色葡萄球菌对阿米卡星等15种临床常用抗菌药物耐药率较高,均＞80％,且呈多药耐药,但对万古霉素、利奈唑胺全部敏感,呋喃妥因耐药率也较低.结论 临床分离的金黄色葡萄球菌中,已出现莫匹罗星高水平耐药的菌株,临床应加强对该类菌株的监测,以减少耐药菌株的产生和流行.

High-level resistance of Staphylococcus aureus to mupirocin

OBJECTIVE To investigate the status of high-level resistance of Staphylococcus aureus(SAU) to mupirocin and the resistance of mupirocin-resistant strains to commonly used antibiotics.METHODS The identification of bacteria and drug susceptibility test were performed with Phoenix100 full-automatic system.The system could detect both methicillin-resistant S.aureus(MRSA) and high-level mupirocin-resistant S.aureus at the same time.RESULTS Totally 382 SAU strains were obtained,in which 25 isolates(6.5%) were high-level mupirocin-resistant(MUH).Among 25 high-level mupirocin-resistant strains,23 strains were methicillin-resistant S.aureus(MRSA),accounting for 92.0%;the drug resistance rates of high-level mupirocin-resistant SAU to amikacin and other common antibiotics were relatively high,which were all over 80.0%.They were multidrug-resistant,however,all the strains were susceptible to vancomycin and linezolid.The resistance rate to nitrofurantoin was low.CONCLUSION Of the clinical isolated SAU,high-level mupirocin-resistant strains have emerged,therefore,the monitoring of high-level mupirocin-resistant SAU isolates should be strengthened in clinical practice in order to prevent it from generation and dissemination.