急性缺血性脑血管病前后炎症因子与脂蛋白的动态观察

目的 考察急性缺血性脑血管病的炎症因子与脂蛋白的变化.方法 收集医院2009年3月-2010年12月109例急性缺血性脑血管病发病前1月内与病后1、5、30 d血清C-反应蛋白(CRP)、白介素-1(IL-1)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(Apo A1)、载脂蛋白B(Apo B)、载脂蛋白E(Apo E)并进行比较.结果 与正常对照组比,缺血性脑血管病患者发病前所测CRP、Apo A1、ApoB、Apo E差异有统计学意义(P＜0.01);IL-1、CRP、Apo A1、Apo B、Apo E发病前分别为(231.00 153.00)pg/ml、(6.31 2.19)mg/L、(1.29 0.29)mmol/L、(0.68 0.15)mmol/L、(3.79 1.28)mmol/L,发病后第1天分别为(290.00±132.00)pg/ml、(12.31 2.64)mg/L、(1.19 0.26)mmol/L、(0.92 0.13)mmol/L、(6.01 1.36)mmol/L,差异有统计学意义(P＜0.01).结论 Apo A1、Apo B和Apo E应列为临床常规血脂检查,C-反应蛋白联合血脂检查可用于预测缺血性脑血管事件的发生可能性.

Dynamic observation of inflammatory cytokines and lipoproteins before and after acute ischemic cerebrovascular disease

OBJECTIVE To study the changes of inflammatory cytokines and lipoproteins in patients with acute ischemic cerebrovascular disease.METHODS From Mar 2009 to Dec 2010,a total of 109 cases of acute ischemic cerebrovascular disease in our hospital were enrolled.The TG,TC,HDL,LDL;Apo A1,Apo B,Apo E within 1 month prior to the illness,the 1st day,5th day and 30th day of treatment were compared.RESULTS Compared with the control,CRP,Apo A1,Apo B,Apo E before ischemic cerebrovascular disease were significantly different(P<0.01).IL-1,CRP,Apo A1,Apo B,Apo E were(231.00±153.00)pg/ml,(6.31±2.19)mg/L,(1.29±0.29)mmol/L,(0.68±0.15)mmol/L,(3.79±1.28)mmol/L,respectively before onset,significantly different from those 1 d after incidence,(290.00±132.00)pg/ml,(12.31±2.64)mg/L,(1.19±0.26)mmol/L,(0.92±0.13)mmol/L,(6.01±1.36)mmol/L(P<0.01),respectively.CONCLUSION C-reactive protein,Apo A1,Apo B and Apo E and blood tests can be used to predict ischemic cerebrovascular disease.