人巨细胞病毒感染与动脉粥样硬化相关性探讨

目的 分析人巨细胞病毒(HCMV)抗体与冠状动脉粥样硬化的相关性.方法 应用ELISA方法,将81例冠状动脉粥样硬化患者作为治疗组,进行血清HCMV抗体检测,并选取44例健康者,作为对照者,进行比较.结果 冠状动脉粥样硬化组HCMV感染阳性率为42.0％,健康对照组为20.5％,两组比较,差异有统计学意义(P＜0.05);单支病变与＞2支病变组HCMV感染经造影检查表明,冠状动脉单支病变36例,阳性8例占22.2％,多支病变者45例,阳性26例占57.8％,差异有统计学意义(P＜0.05).结论 动脉粥样硬化与HCMV感染有一定的相关性,HCMV为动脉粥样硬化的危险因素;检测HCMV抗体可以为动脉粥样硬化进行提示,可应用于临床.

Relationship between coronary atherosclerosis and Human cytomegalovirus infection

OBJECTIVE To investigate the relationship between coronary atherosclerosis and Human cytomegalovirus(HCMV) infection.METHODS HCMV antibody was determined by enzyme-linked immunosorbent assay(ELISA) in 81 cases who had coronary atherosclerosis,and compared with 44 normal controls.RESULTS The positive rate of HCMV infection was 42.0% in the coronary atheroscleros group,and 20.5% in the normal control(P<0.05).The positive rate was 55.6% in multiple vessel disease group,and 44.4% in single vessel disease group(P<0.05).CONCLUSION The levels of HCMV infection were higher in patients with carotid atherosclerosis,which suggested that there was a relationship between the infection of HCMV and carotid atherosclerosis.