综合医院金黄色葡萄球菌的耐药性分析

目的 了解金黄色葡萄球菌的临床分布特点及耐药性,指导临床合理使用抗菌药物.方法 对2010年临床分离的金黄色葡萄球菌进行药敏试验,并用WHONET 5.4软件进行数据分析.结果 2010年共分离出金黄色葡萄球菌219株,其中MRSA检出75株,检出率为34.2％,MSSA检出144株,检出率为65.8％;金黄色葡萄球菌主要来源于分泌物,占54.4％,主要分布于五官科、骨科、神经外科；MRSA对抗菌药物的耐药率显著高于MSSA(P＜0.05),未发现耐万古霉素、利奈唑胺金黄色葡萄球菌.结论 金黄色葡萄球菌对抗菌药物已产生多药耐药性,MRSA、MSSA对抗菌药物的耐药性存在差异,临床医师应结合细菌耐药特点,合理选择抗菌药物,预防和控制耐药菌株的产生.

Drug resistance of Staphylococcus aureusin general hospitals

OBJECTIVE To understand the clinical distribution and drug resistance of Staphylococcus aureus(SAU) so as to guide the clinical use of antibacterial agents.METHODS Drug susceptibility testing for SAU isolated in 2010 was carried out and statistical analysis was performed with WHONET 5.4 software.RESULTS Of 219 strains of SAU isolated in 2010,there were 75(34.2%) strains of MRSA and 144(65.8%) strains of MSSA.SAU strains were mainly isolated from secretions(54.4%),mainly distributed in ENT,orthopedics department,and department of neurosurgery.The drug resistance of MRSA was significantly higher than that of MSSA(P<0.05).No strains of SAU isolates resistant to vancomycin and linezolid were found.CONCLUSION SAU is multidrug-resistant.There is difference in the drug resistance of MRSA and MSSA isolates.Clinicians should select antibiotics rationally according to the characteristics of drug resistance so as to prevent and control the occurrence of resistant strains.