7例布鲁菌病患者的实验室诊断与临床分析

目的 探讨布鲁菌病实验室诊断特征,分析布鲁菌病流行病学、临床特点、治疗和转归,以提高对布鲁菌病的认识.方法 对2006-2009年医院布鲁菌属阳性患者进行回顾性分析.结果 2006-2009年血培养阳性标本中,7例鉴定为布鲁菌属;患者临床表现均有反复发热;确诊后3例患者进行了手术治疗;7例患者经米诺环素、多西环素、利福平、左氧氟沙星4种抗菌药物中联合1～2种治疗后治愈.结论 布鲁菌病临床表现多样,对长期不明原因发热者应及时进行血培养;四环素类、利福平或左氧氟沙星等抗菌药物是有效的治疗手段.

Laboratory diagnosis of 7 cases of brucellosis and clinical analysis

OBJECTIVE To explore the laboratory diagnostic features of brucellosis and analyze the epidemiology,clinical features,treatment and prognosis of brucellosis in order to understand brucellosis better.METHODS General blood culture,isolation and identification of positive bacteria and retrospectively analysis were performed in patients with positive brucellosis in our hospital from 2006 to 2009.RESULTS Totally 7 cases with positive blood cultures were identified as Brucella from 2006 to 2009 and clinical manifestations were recurrent fever,and 3 of them took surgery after confirmed diagnosis.All 7 patients were cured after the combined treatment of minocycline,doxycycline,rifampin and levofloxacin.CONCLUSION Brucellosis varies in its clinical manifestations.Blood culture is an effective diagnostic tool for patients suffering from the long-term fever with unknown reasons.Tetracycline,rifampin,or levofloxacin and other antibiotics are effective.