472株大肠埃希菌分布及耐药性分析

目的 了解医院大肠埃希菌(ECO)的耐药性及其标本来源,为临床治疗及控制医院感染提供依据.方法 对2010年6月-2011年3月临床分离的472株大肠埃希菌的耐药率及标本来源进行回顾性分析.结果 收集的472株大肠埃希菌对亚胺培南、美罗培南、厄他培南的耐药率均为0；对哌拉西林/他唑巴坦、头孢西丁、阿莫西林/克拉维酸、头孢吡肟、头孢他啶、氨曲南、妥布霉素、庆大霉素、左氧氟沙星、环丙沙星、头孢噻肟的耐药率为7.8％～58.5％；对磺胺甲噁唑/甲氧苄啶、头孢唑林和氨苄西林的耐药率分别为63.3％、73.9％、82.0％,472株大肠埃希菌主要从痰液和尿液标本中检出,分别占33.1％和29.0％.结论 大肠埃希菌为呼吸道和泌尿道感染的常见病原随,临床上应根据耐药特点合理选用抗菌药物.

Analysis of drug resistance and distribution of 472 strains of Escherichia coli

OBJECTIVE To investigate drug resistance and specimen sources of Escherichia coli in hospital,so as to guide the clinical treatment and control of nosocomial infections.METHODS A total of 472 strains of E.coli were collected from June 2010-March 2011,and the drug resistance rates and specimen sources were analyzed retrospectively.RESULTS The resistance rates of the 472 strains of E.coli to imipenem,meropenem,and ertapenem were 0;the resistance rates to piperacillin/tazobactam,cefoxitin,amoxicillin/clavulanic,cefepime,ceftazidime,aztreonam,tobramycin,cidomycin,levofloxacin,ciprofloxacin,and cefotaxime varied from 7.8% to 58.5%;the resistance rates to sulfamethoxazole/trimethoprim,cefazolin,and ampicillin were 63.3%,73.9%,and 82.0%,respectively;472 strains of E.coli were mainly detected from sputum(33.1%) and urine(29.0%).CONCLUSION E.coli is the common pathogen which can cause respiratory tract infections and urinary tract infections.Antibiotics should be chosen in the clinical practice according to the characteristics of drug resistance.