生殖道解脲脲支原体与不孕不育的关系及耐药性分析

目的 研究生殖道解脲脲支原体(Uu)感染与不孕不育之间的关系及其耐药性.方法 采用培养技术,对医院不孕不育门诊的160对不孕不育夫妇及30对正常妊娠夫妇生殖道分泌物进行生殖道Uu检测,同时分析菌株的耐药性,对比两组人群生殖道Uu感染的差异性.结果 160对不孕不育夫妇中,男性、女性Uu感染率分别为31.25％、40.62％,30对正常妊娠夫妇中,男、女Uu感染率分别为10.00％、16.67％,不孕组与对照组Uu感染率比较差异有统计学意义(P＜0.05),药敏分析敏感性较高的依次为米诺环素、多西环素、交沙霉素,耐药性最高的是红霉素.结论 不孕不育患者生殖道Uu感染率明显高于正常妊娠人群,Uu感染可能是男女不孕不育的一种诱因,治疗时首先选用敏感性较高的米诺环素、多西环素、交沙霉素.

Relationship between genital tract-derived Ureaplasma urealyticum and infertility and analysis of the drug resistance

OBJECTIVE To investigate the relationship between genital tract derived Ureaplasma urealytium(Uu) infection and infertility,as well as antibiotic resistance. METHODS By culture technique,genital tract secretions from 160 couples with infertility in sterility clinic and 30 couples with normal pregnancy were tested for genital tract Uu.Meanwhile,we analyzed drug resistance of the strains and compared infection with genital tract Uu in the two groups. RESULTS In the 160 couples with infertility,Uu infection rates in male and female were 31.25% and 40.62% respectively.In the 30 couples with normal pregnancy,Uu infection rates in male and female were 10.00% and 16.67% respectively.There was significant difference between the two groups(P<0.05).Drug susceptibility analysis showed the drugs with high susceptibility were minocycline,doxycycline and josamycin.Erythromycin showed the highest resistance rate. CONCLUSION The genital tract Uu infection rate of infertility patients is significantly higher than normal pregnancy population.Uu infection may be an incentive to cause the infertility of men and women.The antibiotics with high sensitivity,such as minocycline doxycycline,and josamycin,should be the first choice for the treatment.