多药耐药铜绿假单胞菌的医院感染现状及耐药性研究

目的 探讨多药耐药铜绿假单胞菌(PAE)的临床分布及耐药性特征,为预防和控制医院感染提供实验室依据.方法 PAE分离、鉴定严格按照《全国临床检验操作规程》进行；药敏试验采用K-B法,依据CLSI最新折点判读结果.结果 167株PAE在呼吸道标本中检出率居首位,占68.2％,在泌尿道标本居第2位,占12.6％；药敏结果表明,PAE对临床常用抗菌药物均产生了非常严重的耐药性,耐亚胺培南铜绿假单胞菌检出率为30.5％,PAE泛耐药菌株检出率为13.8％.结论 应重视PAE耐药性的监测工作,预防与控制多药耐药PAE医院感染的暴发流行.

Current status of nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and its drug resistance

OBJECTIVE To study the clinical distribution and antimicrobial resistance of multidrug-resistant Pseudomonas aeruginosa(PAE) to provide the scientific experimental evidence for clinical prevention and controlling of nosocomial infections. METHODS Referring to National Guide to Clinical Laboratory Procedures,PAE were isolated and identified.The susceptibility testing was performed by K-B methods.The testing results were assessed according to the latest version of CLSI breakpoints. RESULTS The specimen from respiratory tract got the highest detection rate of 68.2%,followed by the specimen from the urinary tract accounting for 12.6%,ranking the second.The susceptibility results indicated that PAE had been resistant to commonly used antibiotics in high degrees.The detection rate of imipenem resistant PAE(IRPAE) was 30.5%,the detection rate of pan-resistant PAE was 13.8%. CONCLUSION Hospitals should attach great importance to monitoring of antimicrobial resistance of PAE to prevent and control the outbreak and prevalence of nosocomial infections caused by multi-resistant PAE.