| BMI-1基因与肿瘤关系研究进展 |
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| 引用本文： | 胡中华,胡义德. BMI-1基因与肿瘤关系研究进展[J]. 中华肿瘤防治杂志, 2006, 13(23): 1824-1827 |
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| 作者姓名： | 胡中华 胡义德 |
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| 作者单位： | 第三军医大学新桥医院全军肿瘤中心,重庆,400037;第三军医大学新桥医院全军肿瘤中心,重庆,400037 |
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| 摘 要： | BMI-1基因为一种致癌基因,属于PcG家族成员,通过抑制INK4a-ARF位点,从而与多种实体瘤的发生发展密切相关;BMI-1基因在维持正常干细胞自我更新及多向分化方面起重要作用;具有促进白血病干细胞增殖的能力。肿瘤干细胞是形成不同分化程度肿瘤细胞和肿瘤不断扩展的源泉,靶向杀死肿瘤干细胞应成为肿瘤治疗的根本目的。
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| 关 键 词： | 核蛋白质类 原癌基因蛋白质类 肿瘤 综述文献 |
| 文章编号： | 1673-5269（2006）23-1824-04 |
| 收稿时间： | 2005-11-02 |
| 修稿时间： | 2006-04-24 |
Study condition of the relationship between BMI-1 gene and tumor |
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| HU Zhong-hua,HU Yi-de. Study condition of the relationship between BMI-1 gene and tumor[J]. Chinese Journal of Cancer Prevention and Treatment, 2006, 13(23): 1824-1827 |
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| Authors: | HU Zhong-hua HU Yi-de |
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| Affiliation: | Department of 0ncology, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, P.R. China |
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| Abstract: | BMI-1, a member of the Polycomb Group (Pc-G) family genes, is a human proto-oncogene. Through inhibiting INK4a-ARF, BMI-1 gene has a deep relationship with many solid tumors. BMI-1 gene play an important role in maintaining self-renewal and multipolar differentiation of normal stem cells, as well as in promoting proliferation of the leukemic stem cells. Tumor stem cells are the source of forming diverse tumor cells and cotinuously spread of tumors, so aimed killing of tumor stem cells should become ultimate purpose of the therapy of tumors. |
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| Keywords: | nuclear proteins proto-oncogene proteins neoplasms review literature |
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