作用于2型糖尿病新靶点的天然产物研究进展

2型糖尿病又称非胰岛素依赖型糖尿病,由胰岛素分泌障碍和组织器官对胰岛素抵抗引起。目前2型糖尿病患者占糖尿病人群的90%以上,严重危害人类健康,然而目前临床应用的化学合成降糖药均有不同程度的副作用。因此,从作用温和、毒副作用小的天然植物提取物中,依据不同的靶点筛选和发现治疗2型糖尿病的活性成分,成为国内外学者的研究热点。现已发现的2型糖尿病的新靶点主要包括蛋白酪氨酸磷酸酶1B(PTP1B)、二肽基肽酶IV(DPP-IV)、过氧化物酶体增殖活化受体(PPAR)和腺苷酸活化蛋白激酶(AMPK)等。现对天然产物中作用于糖尿病新靶点的活性成分研究进展进行综述,以期为开发治疗2型糖尿病新药提供参考。

Research progress on natural products on new targets of type 2 diabetes

Type 2 diabete, caused by inadequate secretion of insulin and insulin resistance in tissues and organs, is also called non insulin dependent diabete. At present, over 90% diabetes is type 2 diabete which is seriously harmful to human health, however, the current clinical application of chemical synthetic medicines have different degrees of side effects. Therefore, the study of components with antidiabetic activity acting on different targets from the natural products with low toxicity has become a focus of current research. The new targets, such as PTP1B, DPP-IV, PPAR, and AMPK, were discovered in recent years. In this paper, active components in natural products on new targets for diabetes are reviewed, so as to provide the reference for the further research of diabetes.