疏肝益肾法对乳腺癌术后内分泌疗法副作用的影响

目的 分析疏肝益肾法对乳腺癌术后雌激素和(或)孕激素受体阳性患者服用三苯氧胺(TAM)副作用的影响, 并以此结论为依据评价中药(疏肝益肾法)能否缓解和消除TAM的副作用进行回顾性研究.方法 采用前瞻性研究方法利用随机、平行、同期手段进行观察.全部病例观察完成后计量资料用t检验或方差分析,计数资料用χ2检验,均值资料用WilcoxOn秩和检验.结果 针对肝郁不疏、肾阴亏虚证用中药干预的结果显示,观察组与对照组治疗前后比较、观察组治疗前后比较, 改善或明显改善的症状为颜面潮红、五心烦热、盗汗、抑郁、失眠、心悸,无改善的为恶心呕吐、月经不调、口苦咽干:生 存质量有所提高.结论 应用中药疏肝益肾法对减轻TAM的相关副作用有效,证明了肝木主动主升、体阴而用阳的中医理论 对肝郁不疏、肾阴亏虚的乳癌患者的治疗指导作用.

The Clinical Study on Management of Side effects of Endocrine Therapy (Tamoxifen) on Breast Cancer Patients in Post Surgery with TCM Treating Principle of Regulating Liver Qi and Tonifying Kidney Yin

Objective By previous overview of patients treated in our hospital, this study highlights on the intervention effects of TCM treating principle of regulating liver Qi and tonifying kidney Yin on the adverse reaction of TAM on breast cancer patients in post surgery. Methods Perspective study with the measures of randomization, and paralleling and synchronization control was conducted in the research. Results symptoms such as flush, insomnia, night sweat, palpitation, depression and heat sensation in the chest, palms and soles were improved significantly; while manifestations such as nausea, vomiting, irregular menstruation, bitter taste and dry mouth showed no significant changes. QOL changed significantly. Conclusion The application of treating principle of regulating liver Qi and tonifying kidney Yin is effective in reducing side effects caused by TAM. This result further improved the theory of TCM that the nature of liver is active, although the liver belongs to Yin in physique and but Yang in function.