Prevalence and genotype characterization of human papillomaviruses among HIV-seropositive in Ouagadougou, Burkina Faso |
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Authors: | Djigma F W Ouédraogo C Karou D S Sagna T Bisseye C Zeba M Ouermi D Gnoula C Pietra V Ghilat-Avoid-Belem N W Sanogo K Sempore J Pignatelli S Ferri A M Nikiema J-B Simpore J |
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Affiliation: | aCentre de Recherche Biomoléculaire “Pietro Annigoni”, CERBA/LABIOGENE, Ouagadougou, Burkina Faso;bUnité de Formation et de Recherche en Sciences de la Vie et de la Terre (UFR/SVT), Université de Ouagadougou, Burkina Faso;cEcole Supérieure des Techniques Biologiques et Alimentaires (ESTBA-UL), Université de Lomé, Togo;dInfectious and Tropical Diseases, University of Brescia, Brescia, Italy;eUniversità degli Studi di Roma “La Sapienza”, Rome, Italy |
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Abstract: | BackgroundApproximately, 15–20 of 40 HPVs that infect the female genital tract confer a high-risk of invasive cancer, thus HPVs account for 95% of cervix cancers. The objectives of this study were to: (i) estimate the prevalence of HPV infection in women infected with HIV in Ouagadougou, (ii) identify potential carcinogenic HPV strains and (iii) determine whether existing HPV vaccines match the isolated strains.MethodsFrom May 2009 to April 2010, 250 HIV-infected women were included in this study. Each woman was screened for the presence of HPV and for HPV genotype using PCR/hybridization technique.ResultsOf the 250 HIV-infected women, 59.6% were infected with at least one type of HPV. High-risk HPVs were identified with the following prevalence: HPV-18 (25.0%); HPV-50′S (25.5%); HPV-30′S (20.8%); HPV-16 (4.7%); HPV-45 (3.7%). Low-risk HPVs were represented by HPV-6 (5.7%) and HPV-11 (0.9%).ConclusionThe issue of the study showed that the existing vaccines: Gardasil and Cervarix may be used in the country although they match only HPV-16, HPV-18, HPV-6 and HPV-11. Further investigations should be continued for the establishment of vaccine that matches all genotypes circulating in the country. |
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Keywords: | HPV HIV/AIDS Genotypes Burkina Faso |
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