急性白血病并发颅内出血死亡23例

统计我所１９９３年１月至１９９４年８月期间急性白血病合并颅内出血死亡病例２３例，死亡原因为血小板减少，高白细胞血症、ＤＩＣ和肝损害等，表明早期死亡组主要与高白细胞血症和血小板减少有关，分析了颅内出血与ＦＡＢ分型，病情缓解与否、化疗、合并感染及贫血的相互关系，得出Ｍ３型，化疗，原发病未控制及合并感染是颅内出血的危险因素的结论。探讨了颅内出血的临床先兆表现。

A Study on 23 Acute Leukemia Cases Died of Intracranial Hemerrhage

Twenty-three patients with acute leukemia(AL)who died of intracranial hemorrhage,treated at our institute from January 1993 to August 1994 were summaried.The analysis indicated.firstly,the causes of hemorrhage were thrombocytopenia,hyperleukocytosis,DIC and liver dysfuction. In the group of early death(ED),hyperleukocytosis and thrombocytopenia were principal causes. Secondly,certain high risk factors were associated with intracranial hemorrhage,such as M5 Subtyre,chemotherapy,infection and failure to control underlying disease.At last,the study provided clinically some prodromal bleeding presentations which may precede life threatening intracranial Hemorrhage.