系统性红斑狼疮患者医院尿路感染相关危险因素分析

为探讨系统性红斑狼疮(SLE)患者医院尿路感染的相关危险因素,回顾性分析了2000年1月~2004年12月某院住院的316例SLE患者。结果显示,SLE患者发生医院尿路感染共28例(8.86%),感染菌以革兰氏阴性菌为主(75.00%)。强的松用量>10m g组尿路感染发生率明显高于激素用量≤10 m g组(29.68%vs 9.86%,P<0.01)。合并应用免疫抑制剂患者尿路感染发生率明显高于单用激素组(33.56%vs 13.25%,P<0.01)。留置导尿管患者尿路感染的发生率明显升高。另外,住院时间越长,累及的脏器数越多,越易发生尿路感染。尿路感染组C反应蛋白(CRP)水平明显高于未感染组(P<0.01)。因此,尿路感染是SLE患者医院感染的常见形式之一,SLE患者医院尿路感染的相关危险因素为性别、住院天数、激素及免疫抑制剂的应用、是否留置导尿管、累及的脏器数等。CRP是区分SLE是否发生尿路感染的一个有用指标。

Risk Factor of Nosocomial Urinary Tract Infection in Patients with Systemic Iupus Erythematosus

Objective: To investigate nosocomial urinary tract infection in patients with systemic lupus erythematosus(SLE).Methods: A total of 316 in-patients from Jan.2000 to Dec.2004 in our hospital were investigated retrospectively.Results: The nosocomial urinary tract infection rate was 8.86% in patients with SLE.The predominant pathogen of nosocomial urinary tract infection was Gram negative bacilli(75.00%).The occurrence of nosocomial urinary tract infection was associated with gender,nosocomial duration,the dosage of prednisone and the combined administration of immunosuppressive agents,urethral catheter used,and injured organs.The level of C-reactive protein(CRP) was higher in the patients with urinary tract infection than that in controls(P<0.01).Conclusion: Urinary tract infection is one of the common nosocomial infection in patients with SLE.The main risk factors of nosocomial urinary tract infection in patients with SLE are gender,nosocomial duration,the dosage of prednisone and combined administration of immunosuppressive agents,urethral catheter used,and injured organs.The level of CRP may help to differentiate nosocomial urinary tract infection from the patients with SLE.