Interleukin levels in cerebrospinal fluid from children with neurocysticercosis. |
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| Authors: | F Aguilar-Rebolledo R Cedillo-Rivera P Llaguno-Violante J Torres-López O Mu?oz-Hernandez J A Enciso-Moreno |
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| Affiliation: | Departamento de Neurología, Hospital de Pediatría, CMN Siglo XXI, IMSS, Mexico DF, México. |
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| Abstract: | No information about the levels of pro-inflammatory interleukins has been described in children with neurocysticercosis (NCC). The levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-5, IL-6, and IL-12 in the cerebrospinal fluid from children with NCC were determined by enzyme-linked immunosorbent assay (ELISA). Twelve children with NCC, six with active and six with inactive disease, and six children without NCC were studied. TNF-alpha was undetectable in CSF from controls and five children with inactive NCC, whereas the levels were significantly higher (median 22.1 pg/ml; P = 0.008) in all children with active NCC. Levels of IL-6 were low in active and inactive NCC patients but two subjects with active subarachnoid disease had high levels. IL-5 and IL-12 were not detected. This study shows that high levels of TNF-alpha are present in CSF from children with active NCC. IL-6 levels are higher when infection occurs in the subarachnoid space. |
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