孕妇TORCH感染与胎儿畸形的关系

目的: 探讨孕妇TORCH感染与胎儿畸形的关系. 方法: 采用酶联免疫吸附试验 (ELISA)法检测1000例孕妇血清TORCH的特异性抗体IgM,对检测抗体阳性者和有畸胎史、不良孕产史的孕妇,用PCR法来检测TORCH DNA. 结果: 孕妇TORCH IgM阳性率为11.6%,其TOX, RV, HCMV, HSV IgM阳性率分别为3.60%, 2.50%, 3.40%, 2.10%;母婴垂直传播率为33.33%,其中TOX, RV, HCMV, HSV的垂直传播率分别为43.33%, 26.32%, 34.62%, 18.18%;孕妇妊娠期间有上感症状者感染TORCH IgM阳性率21.51%显著高于无上感症状者9.34%(P<0.01);有畸胎史TORCH IgM阳性率42.10%、不良孕产史25.40%,显著高于正常妊娠者8.13%(<0.01)TORCH感染孕妇其胎儿畸形率12.37%显著高于无感染组1.07% (<0.01) 结论: 孕妇TORCH感染是导致胎儿畸形的重要因素.

Study of TORCH infection in pregnant women and fetal abnormalities

AIM: To study the relationship between TORCH infection in pregnant women and fetal abnormalities. METHODS: Enzyme linked immonosorbent assay (ELISA) was applied to detect TORCH IgM in the serum of 1000 pregnant women and TORCH DNA in the blood of pregnant women with TORCH IgM positive and abnormal pregnancy history was detected by polymerase chain reaction (PCR). RESULTS: The pregnant women TORCH IgM positive rate was 11.60%, TOX, RV, HCMV, HSVIgM positive rate was respectively 3.60%, 2.50%, 3.40% and 2.10%.The rate of TORCH intrauterine was 33.33% and that of TOX, RV, HCMV, HSV was respectively 43.33%, 26.32%, 34.62%, and 18.18%. The TORCH IgM positive rate of pregnant women with flu symptoms (21.51%) was significantly higher than that (9.34%) of women without flu symptoms (P<0.01). The TORCH IgM positive rate of pregnant women with fetal abnormality history (42.10%), or with abnormal pregnancy history (25.40%) was also significant higher than that (8.13%) of women with normal pregnancy(P<0.01). The rate of fetal abnormality (12.37%) in TORCH DNA positive group was significantly higher than that (1.07%) of negative group (P<0.01). CONCLUSION: TORCH infection in pregnant women is a factor causing fatal abortion and abnormalities.