| 甲亢患者IL-4、IL-10水平检测的临床意义 |
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| 引用本文： | 陈跃,甘西伦,陈佰勋,张春银,张莉,邱陵.甲亢患者IL-4、IL-10水平检测的临床意义[J].放射免疫学杂志,2003,16(4):196-198. |
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| 作者姓名： | 陈跃 甘西伦 陈佰勋 张春银 张莉 邱陵 |
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| 作者单位： | 四川泸州医学院附属医院核医学科,646000 |
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| 摘 要： | 目的 :探讨IL - 4、IL - 10水平变化在甲亢的临床意义。方法 :选择甲亢未治疗组 6 4例、甲亢经1 31 I治疗组 39例和正常对照组 35例 ,用化学发光法测定FT3、FT4 、TSH的含量 ,用放射免疫分析测定IL - 4、IL - 10含量。结果 :甲亢未治疗组患者血清IL - 4、IL - 10水平均高于正常对照组 (p <0 0 1、p <0 0 5 )。1 31 I治疗组患者血清IL - 4、IL - 10水平均低于未治疗组 (p <0 0 1、p <0 0 5 )。甲亢1 31 I治疗组患者血清IL - 4、IL - 10与正常对照组差异无显著性 (p>0 0 5 )。结论 :IL - 4、IL - 10在甲亢的发病机理中起重要作用 ,判断疗效有一定意义。
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| 关 键 词： | 甲亢 IL-4 IL-10 检测 临床意义 白细胞介素4 白细胞介素10 |
| 修稿时间： | 2003年5月15日 |
Clinical Significance of Changes of Serum IL-4 and IL-10 Levels in Patients with Graves' Disease |
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| Chen Yue,Gan Xilun,Zhang Chunying,Chen Baixun,Zhang Li,Qiu Lin.Clinical Significance of Changes of Serum IL-4 and IL-10 Levels in Patients with Graves'''' Disease[J].Journal of Radioimmanology,2003,16(4):196-198. |
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| Authors: | Chen Yue Gan Xilun Zhang Chunying Chen Baixun Zhang Li Qiu Lin |
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| Abstract: | Objective To explore the clinical significance of changes of serum IL-4 and IL-10 in patients with Graves' Disease. Methods Serum thyroid bormones (FT 3, FT 4, TSH, with chemiluminescence method) and cytokines (IL-4, IL-10 with RIA) levels were measured in 138 individuals, consisting of 64 patients with untreated Graves' disease, 39 patients with Graves' disease treated with 131 I and 35 controls. Results Serum IL-4 and IL-10 levels in patients before treatment were significantly higher than those in controls ( p<0 01, p<0 05 respectively). After successful treatment, the levels dropped, being significantly lower than those before treatment ( p<0 01,p <0 05) and not much different from those in controls ( p >0 05). Conclusion IL-4 and IL-10 played impontant role in the development of Graves' diseace. Returning from high serum levels towards normal reflected the treatment effectiveness. |
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