| 阵发性睡眠性血红蛋白尿症血栓前状态部分指标的检测 |
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| 引用本文： | 薛重重,李大钧,和虹,王钧,李智存,范雅丽,吴雅锋.阵发性睡眠性血红蛋白尿症血栓前状态部分指标的检测[J].血栓与止血学,1998(1). |
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| 作者姓名： | 薛重重 李大钧 和虹 王钧 李智存 范雅丽 吴雅锋 |
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| 作者单位： | 河北省沧州市中心医院 061001
(薛重重，李大钧，和虹，王钧，李智存，范雅丽)，河北省沧州市中心医院 061001(吴雅锋) |
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| 摘 要： | 目的:了解PNH患者凝血、纤溶及血小板功能变化,从而对PNH患者有关的血栓前状态进行评估。方法:vWF:Ag、GMP-140采用酶联免疫法;t-PA:A、PAI:A采用发色底物法;PAgT采用TYXN-91凝血仪,ADP为诱导剂。结果:PNH组 vWF:Ag、GMP-140、t-PA:A与PAgT均明显高于对照组(P<0.01,P<0.05),PAI:A无显著性变化(P>0.05)。结论:PNH患者存在血管内皮细胞损伤与血小板活化,从而有利于血栓形成。
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| 关 键 词： | 阵发性睡眠性血红蛋白尿 血栓前状态 |
Detection of some interns of prethrombotk state in patients with paroxysmal nocturnal hemoglobinuria |
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| Xue Zhongahong,Li Dajun,He Hong,et al Changzhou Central Hospital,Hebei.Detection of some interns of prethrombotk state in patients with paroxysmal nocturnal hemoglobinuria[J].Chinese Journal of Thrombosis and Hemostasis,1998(1). |
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| Authors: | Xue Zhongahong Li Dajun He Hong Changzhou Central Hospital Hebei |
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| Institution: | Xue Zhongahong,Li Dajun,He Hong,et al Changzhou Central Hospital,Hebei,061006 |
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| Abstract: | Objective:To explore the changes of coagulation, fibrinolysis and platelet function in order to evaluate evalute the prethrombotic state in patients with paroxysmal nocturnal hemoglobinuria (PNH). Methods:Five parameters concerning endotheliocytes, platelets and fibrinolysis were measured in 26 PNH patients. Results: The results showed that there was no difierence of PAI: A between patients with PNH and normal controb, where vWF: Ag, t - PA: A, CMP - 140 and PAgT were much higher in patients with PNH. There was no markedly dif-fence of five parameters between patients with hemoglobinuria and without hemoglobinuia. Conclusion: Prethrombotic state is present in PNH patients, which may be caused by injury of vascular endothelium cells, high platelets activity and low fibrinolyric activity. |
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| Keywords: | Hemoglobinuria \ paroxyamal nocturnal prethmnbodc state |
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