三苯氧胺治疗乳腺增生病对照试验的系统评价

目的:评价三苯氧胺治疗乳腺增生病的疗效和安全性。方法:通过对MEDLINE、EMBASE、BIOSIS 以及Cochrane图书馆对照试验资料库,中国生物医学文摘数据库的机检和手工检索文献的参考文献,选取采用三苯氧胺和中药治疗乳腺增生病的临床对照试验,进行系统评价。中药的剂型、服用方法、疗程不限。结果:5篇试验,包含3089名患者符合纳入标准,其中有3篇提到随机分组。合并结果表明,三苯氧胺治疗乳腺增生病有一定疗效,无效的相对危险度(relative risk,RR)为1．88,95％,可信区间(confidence intervals,CI)为0．22-15．72]。试验报告有明显副作用,但能在停药后逐渐消失。结论:根据本系统评价,三苯氧胺治疗乳腺增生病有一定疗效,但有可逆的不良反应。然而,由于试验的方法学质量普遍较低,且可能存在发表偏倚,所以目前尚无足够的证据支持它的疗效和安全性,还需要进一步规范的大样本试验。

Tamoxifen for Mastoplasia:A Systematic Review

Objective:To evaluate the efficacy and safety of tamoxifen for mastoplasia.Methods: Searches were applied to following electronic databases:MEDLINE,EMBASE,BIOSIS and Cochrane Library. Chinese conference proceedings were hand-searched. Those control trials, in which patients were treated with tamoxifen and traditional Chinese medicine, were selected. The dosage , using method and course of treatment of tamoxifen were not restricted. Results: 5 trials, including 3 089 patients, met the inclusion criteria,and 3 of them mentioned random grouping. The combined resuits showed that it had a certain positive effect to treat mastoplasia with tamoxifen. (the relative risk of no avail was 1. 88, 95% confidence interval was 0. 22 -15. 72). Side-effects were reported in these trials,but it graduated away after stopping the treatment.Conclusions:According to the systematic review,treatment with tamoxifen for mastoplasia has a certain positive effect, but may produce reversible side-effect. However, the evidence is not enough due to the general low methodological quality. Trails with large samples are needed.