| 氧化应激与细胞凋亡关系的研究进展 |
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| 引用本文： | 褚启龙,杨克敌,王爱国. 氧化应激与细胞凋亡关系的研究进展[J]. 卫生研究, 2003, 32(3): 276-279 |
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| 作者姓名： | 褚启龙 杨克敌 王爱国 |
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| 作者单位： | 华中科技大学同济医学院公共卫生学院,武汉,430030 |
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| 基金项目： | 国家自然科学基金资助项目 (No .30 2 71 1 53) |
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| 摘 要： | 大量研究表明 ,氧化应激可导致细胞凋亡。目前对这一现象有四种解释 :ROS活化核转录因子KB并诱导核转录因子 -KB表达 ,导致细胞凋亡 ;线粒体介导的细胞凋亡 ;ROS导致DNA损伤 ,激活P5 3诱导细胞凋亡及ROS激活SAPK通路介导细胞凋亡。但从总体上看 ,其分子机制还不十分清楚 ,有待进一步研究
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| 关 键 词： | 氧化应激 细胞凋亡 活性氧 |
| 文章编号： | 1000-8020(2003)03-0276-04 |
| 修稿时间： | 2002-02-02 |
Research progress on oxidative stress and apoptosis |
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| Chu Qilong,Yang Kedi,Wang Aiguo School of Public Health,Tongji Medical College of Huazhong University of Science and Technology,Wuhan ,China. Research progress on oxidative stress and apoptosis[J]. Journal of hygiene research, 2003, 32(3): 276-279 |
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| Authors: | Chu Qilong Yang Kedi Wang Aiguo School of Public Health Tongji Medical College of Huazhong University of Science Technology Wuhan China |
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| Affiliation: | School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. |
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| Abstract: | Many research findings revealed that oxidative stress may induce apoptosis. At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis. In this paper, the progress on oxidative stress and apoptosis was reviewed. |
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| Keywords: | oxidative stress apoptosis reactive oxygen species |
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