静脉注射与口服MTX治疗银屑病临床疗效观察 |
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引用本文: | 罗权,李常兴,何玉清,林玲,黄振明,张锡宝. 静脉注射与口服MTX治疗银屑病临床疗效观察[J]. 中国皮肤性病学杂志, 2006, 20(7) |
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作者姓名: | 罗权 李常兴 何玉清 林玲 黄振明 张锡宝 |
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基金项目: | 广东省医药卫生科研项目 |
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摘 要: | 目的评价MTX治疗银屑病的两种给药方案的疗效和安全性。方法将68例银屑病患者随机分为两组。口服组:MTX片2.5~5.0 mg口服,12 h 1次,1周内连续3次。注射组:MTX注射液7.5~15.0 mg静滴,每周1次。两组疗程均为4周。结果口服组与注射组的有效率分别为87.1%和81.1%,有效率比较差异无显著性(P>0.05)。两种方法治疗前后PASI评分差异无显著性。且口服组较注射组不良反应发生率低。结论MTX治疗银屑病的两种给药方案均有确切疗效,但口服给药副作用更少。
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关 键 词: | 银屑病 甲氨蝶呤 |
Observation of Clinical Efficacy on Oral or Ⅳ MTX in Treatment of Psoriasis |
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Abstract: | Objective To evaluate the efficacy and safety of two ways of methotrexate(MTX) for the treatment of psoriasis.Methods 68 patients with psoriasis were randomly divided into two groups,oral group:MTX 2.5-5.0 mg,tab per 12 h,3 times per week;intravenous group:7.5-15.0 mg,one time every week.Results There were no statistically significant differences between the two groups in terms of clinical efficacy(P>0.05).Adverse effects were lower and mild in the oral group.Conclusion The study indicates that two ways of treatment are effective for psoriasis,and the oral treatment has lower side effects. |
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Keywords: | Psoriasis Methotrexate |
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