丙烯酸甲酯的毒性研究

本文报告丙烯酸甲酯的急性和慢性毒性。主要急性毒作用是刺激作用及对中枢神经系统的作用。对大鼠、小鼠和家兔的LC_(50)分别为6400mg/m~3、8800mg/m~3及6800mg/m~3。对大鼠经口LD_(50)为0.27g/kg。对家兔经皮LD_(50)为0.7ml/kg。引起家兔呼吸数减少的急性阈浓度为80mg/m~3。对人的嗅阈为1.5mg/m~3,刺激阈浓度为31mg/m~3。慢性染毒,在840mg/m~3和100mg/m~3组大鼠,动物体重增长缓慢、白细胞数减少、T淋巴细胞数减少,SGPT与SGOT有升高的趋势。20mg/m~3组,除白细胞数减少外,其余指标均未见改变。病理改变主要是肺、肝、肾等内脏器官充血、出血、炎症细胞浸润及细胞变性坏死。

STUDY ON THE TOXICITY OF METHYLACRYLATE (MA)

The paper reports the acute and chronic toxic effect of MA. The main acute toxic effects of MA were irritant effects on mucous membrane and CNS. The LC50 of MA for rats, mice and rabbits were 6400, 8800 and 6800mg/m3 respectively. The oral LD50 of MA for rats was 0.27g/kg. The percutaneous LD50 of MA for rabbits was 0.7ml/kg. The threshold concentration for the temporal decrease of respiratory rate in rabbits was 80mg/m3. The threshold values for odor identification and irritation sensition in men were 1.5mg/m3 and 31mg/m3 respectively. In chronic toxicity test, it was found that, the body weight retarded, the loucocyte and T-lymphocyte counts decreased and the GPT and GOT values increased in the 840mg/m3 and the 100mg/m3 group, but no abno-mality, except leucopenia, was observed in the 20mg/m3 group. The main pathological changes were congestion, hemorrhage, inflammatory cell infiltration, cell degeneration and necrosis in lung, liver and kidney tissues.