合理使用氨苄青霉素实验研究浅析

临床上氨苄青霉素采用一日一次大剂量给药方案,使静点开始阶段血药水平过高,容易造成药热等不良反应,并由于半衰期很短,一天之中大部分血药浓度达不到治疗水平,进行实验研究,用微生物法测定了家兔血清中氨苄青霉素的浓度,以此结果提出了一天静滴两次或静滴和口服相结合的合理用药方案。

Preliminary Study of the Reasonable Use of Ampicillin

In the clinical treaty, the ampicillin is injected a large amount once a day by intravenous drip. It makes the too high level of blood concentration at the initial stage and easy produces the side effect resembling the fever caused by drugs. Since its half-life is very short, in the most of a day, the blood concentration can not reach thie curable level. Detected the plasma concentration of ampicillin in rabbits according to the times by using the methods of microbiology. The results show that the reasonable usage plan is intravenous drip twice a day or combination of the intravenous drip with the per os.