1，2-丙二醇，月桂氮蕈酮—胰岛素传递体经糖尿病小鼠透皮吸收降糖效果研究

目的:研究1,2-丙二醇,月桂氮芯卓酮—胰岛素传递体经皮给药系统对小鼠血糖水平的影响。方法:用超声法制备1,2-丙二醇,月桂氮卓芯酮—胰岛素传递体经皮给药系统,用血糖仪测定血糖含量。对小鼠分别进行了胰岛素传递体和1,2-丙二醇,月桂氮卓芯酮—胰岛素传递体药效学比较。结果:1,2-丙二醇,月桂氮卓芯酮—胰岛素传递体经皮给药系统与胰岛素传递体相比,是其透皮吸收效率的2~3倍,体内药效持续时间也相应延长。2%和6%月桂氮卓芯酮,1,2-丙二醇,—胰岛素传递体经皮给药3h后,小鼠血糖水平分别降为初始值的29.7%和27.9%,5h分别为26.6%和23.7%;腹腔注射胰岛素3h后,小鼠血糖水平降为20.6%,5h后降为33.3%。胰岛素传递体对照组经皮给药3h后,小鼠血糖水平降为75.0%,5h后降为70.3%。结论:1,2-丙二醇,月桂氮卓芯酮—胰岛素传递体经皮给药系统可进一步提高胰岛素传递体的透皮吸收效率,降低血糖。

Efficiency of transfersulin system with azone and 1,2-propanediol in mice

OBJECTIVE To study the effect in blood glucose level in mice with azone and 1,2-propanediol transfersome suspension.METHODS The transfersulin was prepared by ultrasonication,the blood glucose level was measured by blood glucose monitoring system.RESULTS The penetration efficiency for transfersulin system with azone and 1,2-propanediol was about 2-3 times of traditional transfersulin.The changes in blood glucose level(D%) in alloxan-diabetic mice following the 3 h and 5 h transdermal application of 2%azone transfersulin were 29.7% and 26.6% respectively,and the 6% azone 27.9% and 23.7% respectively.While in the ip group they were 20.6% and 33.3% respectively,and in the traditional transfersulin group they were 75.0% and 70.3% respectively.CONCLUSION Transfersulin system with azone and 1,2-propanediol can improve the penetration efficiency on mice skin and eliminate the blood glucose.